BIO – Dr. Magid Abou-Gharbia

Dr. Magid Abou-Gharbia

Dr. Abou-Gharbia received his BS in Pharmacy & Pharmaceutical Sciences in 1971, MS in Medicinal Chemistry in 1974 from the faculty of Pharmacy, Cairo University, and PhD in 1979 from The University of Pennsylvania under Professor Madeleine Joullié followed by a two-year NIH Postdoctoral Fellowship at Medical School, Temple University. Magid joined Wyeth Drug Discovery and Development in 1982 as senior scientist and advanced through roles of increasing responsibility to Senior Vice President & Head of Chemical & Screening Sciences.

In this position, he has built a strong multi-disciplinary Chemical & Screening Sciences (CSS) organization. During his tenure he has fostered a highly creative environment based on modern drug discovery technologies and enhanced chemistry skills and capabilities via the recruitment of high caliber scientists. In his current role he oversees Wyeth’s Chemistry and Screening Discovery research efforts of over 500 scientists at the four Discovery research sites in Collegeville, PA; Princeton, NJ; Pearl River, NY, & Cambridge, MA and 150 chemists at GVK Bio in Hyderabad, India.

Pharma R&D Achievements: Over the years his group research efforts led to the discovery of four marketed drugs and many compounds currently under clinical evaluation including: first-in-class Antidepressant EffexorÒ; Anticancer Agent MylotargÒ; an anticancer rapamycin derivative, ToriselÔ (temsirolimus); an SNRI Anti-depressant, PristiqÒ (DVS-233); a Broad Spectrum Antibiotic TygacilÒ, and a Non-Steroidal HRT ViviantÔ, (BazedoxifeneÒ).

Scientific Contributions include over 180 invited lectures, presentations and publications; inventor on 99 US-issued US patents and over 350 patents worldwide. Awards include: Alfred Burger Award in Medicinal Chemistry (2008), American Institute of Chemists (AIC) Chemistry Pioneer Award (2007), Fellow of the Royal Society of Chemistry (FRSC 2006), Researcher of the Year (2006) from Health Care Institute of NJ (HINJ); Trailblazer Award (2006) from Science Spectrum; Induction into the New Jersey Inventors Hall of Fame (2004); The Procter Medal (2003); ACS Earle B. Barnes Award (2001); Philadelphia Organic Chemists Club (POCC) Award (2001); Egyptian Pharmaceutical Society Drug Discovery Award (2000); Named in list of most Prolific Inventor of the Decade by US Patent & Trade Mark (1998); ACS-Philadelphia Section Award (1997); Wyeth-Ayerst Exceptional Achievement Award (1992); and others.

Scientific and Professional Activities include C&EN Advisory Board, ACS Corp. Associates & Award Canvassing Committees, SFN, AAAS, NYAS, The Royal Society of Chemistry (FRSC), Board of Visitors, Temple U. Pharmacy School, and the Editorial and Scientific Advisory Boards of many journals.

Academic Appointments: Adjunct Professor of Medicinal Chemistry at Temple University, Northeastern University, Center of Drug Discovery (CDD), Cairo University and the University of Ferrara, IT.

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One Response to BIO – Dr. Magid Abou-Gharbia

  1. Dear Dr. Abou-Gharbia;
    Would it be possible to persuade you to give a talk about anacardic acids at the upcoming convention, or if not you, maybe one of your graduate students? It could be along the lines of the passage below and additional information can be obtained in http://charles_w.tripod.com/tooth.html ;
    Anacardic Acids to Cure Gram Positive Infections
    It has been found that anacardic acids with a 15 carbon unsaturated side chain found in the cashew plant is very lethal to gram positive bacteria. The side chain with three unsaturated bonds was the most active against Streptococcus mutans, the tooth decay bacterium, in test tube experiments. The number of unsaturated bonds were not material against Propionibacterium acnes, the acne bacterium [Kubo I, Muroi H, & Himejima M. 1993 Structure – Antibacterial activity relationships of anacardic acids. Journal of Agricultural food Chemicals 41; 1016-1019, on p1018.]. Eichbaum claims that one part to 200,000 to as high as 2,000,000 parts of solution of anacardic acid is lethal to gram positive bacteria in 15 minutes in vitro. Somewhat higher ratios killed tubercle bacteria of tuberculosis in 30 minutes [Eichbaum FW 1946 Biological properties of anacardic acid (O- pentadeca dienylsalicylic acid) and related compounds. General discussion-bactericidal action. Memorias do Instituto Butanen 19 71-86.]. Anacardic acids have been successfully made use of for curing tooth abscess infections [Weber C.E, 2005 Eliminate infection (abscess) in teeth with cashew nuts. Medical Hypotheses 51; 289-292.]. I suggest that it would be a very good idea to test anacardic acids against tuberculosis, leprosy, and acne since they are gram positive bacteria and make these antibiotics available in pure form.

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